CYP2C9 Gene Analysis of Some Iranian Hypersensitive Patients to Warfarin
نویسندگان
چکیده
منابع مشابه
Identification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy
BACKGROUND Although catalytic properties of different genetic polymorphisms of VKORC1 and CYP2C9 products have been identified, there is limited study available regarding warfarin dose requirement in Iranian patient population. This study investigates the impact of these polymorphisms on 115 patients, referred to Payvand Clinical and Specialty Laboratory for determining the appropriate dose of ...
متن کاملidentification of cyp2c9 and vkorc1 polymorphisms in iranian patients who are under warfarin therapy
background: although catalytic properties of different genetic polymorphisms of vkorc1 and cyp2c9 products have been identified, there is limited study available regarding warfarin dose requirement in iranian patient population. this study investigates the impact of these polymorphisms on 115 patients, referred to payvand clinical and specialty laboratory for determining the appropriate dose of...
متن کاملThe relationship between CYP2C9 gene polymorphisms and upper gastrointestinal bleeding in patients who used warfarin.
AIM Oral anticoagulants are the most common used substance for treatment and prophylaxis of warfarin venous and arterial thromboembolic disorders in the world. Therapeutic index of warfarin is narrow. CYP2C9 is a hepatic microsomal enzyme and has a primary role in metabolism of warfarin and genetic variations of CYP2C9 may cause a serious effect on the response to warfarin in patients. The aim ...
متن کاملTesting of VKORC1 and CYP2C9 alleles to guide warfarin dosing
Warfarin is an oral anticoagulant that is widely prescribed to prevent thromboembolic events in persons at increased risk. The optimal dose is difficult to establish because it can vary 10-fold among individuals due to clinical and demographic factors. Testing for variants of the vitamin K epoxide reductase complex 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) genes has been proposed for use in g...
متن کاملextensions of some polynomial inequalities to the polar derivative
توسیع تعدادی از نامساوی های چند جمله ای در مشتق قطبی
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ژورنال
عنوان ژورنال: Pakistan Journal of Biological Sciences
سال: 2009
ISSN: 1028-8880
DOI: 10.3923/pjbs.2009.1160.1163